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谢邀。
曾老师说得很正确,免疫屏障已经基本建立了。
所以下面就顺理成章地进入日常维护阶段了。
那么……这道坚不可摧的免疫马奇诺防线,到底需要怎么好好维护呢?
其实很简单,群体免疫界的领头羊大英帝国,早已帮各位探好路了。
请品鉴牛津大学理论流行病学教授Sunetra Gupta老师的精辟总结:
金句摘选:“maintenance of herd immunity through constant reinfection”.
所以情况就是这么个情况:
在座各位,你们准备好了吗?
最后,请容许我——一个仍然身处免疫洼地无边苦海中载浮载沉的猥琐钉子户——向已经飞升免疫世界之巅的各位勇士致以最崇高的敬意。
————2023年2月2日第一次更新————
评论区有人说咱划重点不划整句,是断章取义。
那么下面就把全文贴过来吧,各位有空不妨读一读全文,
看看上面划重点的操作是不是断章取义:
When the spread of a new pathogen causes severe disease and death in any sector of the population, many decisions have to be made on the basis of very little information. Many speculated that Covid-19 would share a similar fate to Sars, which was virtually eradicated, but it has stubbornly resisted all attempts at elimination and instead more closely followed the expected behaviour of the other seasonal coronaviruses, moving from an epidemic phase into an endemic state with an appropriate reduction in mortality.
With the omicron variant, we know that the fatality rate will be dramatically lower whether or not it has diminished in virulence, because most of what we are seeing is re-infections or vaccine breakthroughs.
This strongly endorses the immediate lifting of restrictions given their devastating consequences, and focusing policy instead on the vulnerable. The low risk of infection among the vulnerable arises from the maintenance of herd immunity through constant reinfection; any measure that interferes with this actually increases their risk.
Self-isolation is a case in point. It may slow the spread of the virus but to what end? Meanwhile, such a requirement causes immense disruption to the normal functioning of society and our ability to provide healthcare and education to those in need.
In order to move fully into “living with the virus”, it is essential to recognise that trying to limit its spread is not only extremely difficult but also undesirable if we are aiming for the sort of relationship we have established with other endemic coronaviruses.
Acknowledging that any attempt to limit the spread of infection is actually retrograde to society is a difficult step to take, and easily lends itself to being characterised as a “let-it-rip” strategy. Yet the implementation of non-pharmaceutical measures such as self-isolation can actually cause more damage to the vulnerable, both by preventing the build-up of herd immunity and because they may be incompletely protected while the virus nonetheless still spreads and herd immunity inevitably accumulates (the “let-it-drip” scenario).
The option of living with the virus, without submitting to the endless cycle of testing and self-isolation, has been tried and tested with the other seasonal coronaviruses and the good news is it seems to work. The alternative is not only pointless but ultimately unworkable within a society that seeks to look after its children, the elderly, the sick and the poor, and would prefer to prevent a widening of the gulf between those who can afford the luxury of self-isolation and those who simply cannot.
It is vital, in any national conversation going forward, to recognise that the omicron wave has been milder not because of its inherent properties but because it has arrived in a landscape where most people have already been naturally exposed to or vaccinated against Covid, so that the vulnerable among them already have immunity against severe disease and death.
Some have suggested that omicron gave us a lucky break. This is mistaken. While some very elegant studies have shown that this variant has some clear functional differences from its antecedents, there is no reason to believe it is intrinsically less virulent or more transmissible. It is a myth that all viruses evolve in this direction.
This means that we did not need to wait for omicron to happen before lifting the restrictions that have caused so much damage to so many. The Prime Minister today announced that Plan B measures, including mask wearing, will end. But he should go further and address Plan A measures, such as self-isolation. 原文传送门:
Why it's time to end Covid self-isolation |
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