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是题主自以为“化疗和免疫治疗不能同时进行”吧?要么,Chemoimmunotherapy 这个单词怎么会出现?
举两个例子:
1、Canadian Cancer Trials Group. A phase II/III randomized study of pembrolizumab in patients with advanced malignant pleural mesothelioma [Internet]. clinicaltrials.gov; 2022 Jan. Report No.: NCT02784171. Available from: https://clinicaltrials.gov/ct2/show/NCT02 784171. This multi-center, randomized, open-label phase II/III trial in Canada, France, and Italy is investigating pembrolizumab (anti-PD1 agent) in combination with frontline chemotherapy and as single agent maintenance therapy versus frontline chemotherapy alone. The study is active but not recruiting, and estimated completion is December 2022.
2、Nowak A, Kok P, Lesterhuis W, Hughes B, Brown C, Kao S, et al. OA08.02 DREAM - a phase 2 trial of durvalumab with first line chemotherapy in mesothelioma: final result. Journal of Thoracic Oncology. 2018; 13: S338-9. This multi-center, openlabel phase II trial in Australia examined the effect of durvalumab (anti-PD-L1 agent), given during and after first-line chemotherapy with cisplatin and pemetrexed in patients with advanced MPM. 57% of patients were alive and progression free at 6 months, prompting a randomized phase III trial DREAM3R.
实际上国内也有化疗和免疫治疗药物同时使用的案例。 |
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