急性髓系白血病癌症基因检测

yijuanyun

xGen® AML Cancer Panel v1.0包含11,743条xGen  Lockdown® Probes,涵盖1.19Mb人类基因，目标富集区域包含超过260个有关AML的基因，可提供更有效的致病突变的检测。

特点：

·探针单独合成与质控

·11,743条xGen® Lockdown Probes锁定的区域内包含260个基因

·通过对200个AML病人进行全基因组与外显子测序定义目标区域

·适用于IDT优化过的xGen4小时捕获Protocol

xGen® AcuteMyeloid Leukemia Cancer Panel包含多基因

ASXL1	FAM154B	IDH2	KDR	NPM1	PRAMEF2
C17orf97	FAM47A	JAK1	KIT	NRAS	PTPN11
CBL	FAM5C	JAK2	KRAS	NTRK3	RUNX1
CEBPA	FLRT2	JAK3	LRRC4	OR13H1	TET2
DNMT3A	FLT3	KCNA4	MLL3	OR8B12	TP53
EGFR	GJB3	KCNK13	MYC	P2RY2	TUBA3C
EZH2	IDH1	KDM6A	NF1	PCDHB1	WT1

Table 1. Frequently Researched GenesIncluded in the xGen® AML Cancer Panel. Thepanel does not target every exon in each gene, but targets all regions found tobe mutated in the TCGA study. For a complete list of genes.

文献

Cancer Genome AtlasResearch Network (2013) Genomic and epigenomic landscapes of adult denovo acutemyeloid leukemia. N Engl J Med, 368(22):2059–2074

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